ANNEXIN IV Meaning and
Definition
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Annexin IV, also known as annexin A4, is a protein that belongs to the annexin family of calcium-dependent phospholipid-binding proteins. It is encoded by the ANXA4 gene in humans. Annexin IV is primarily found in various tissues and organs, including the kidney, stomach, intestine, and colon.
This protein plays a significant role in a variety of cellular processes, particularly in the regulation of ion transport, signal transduction, and calcium homeostasis. It has been identified as a calcium-dependent phospholipid-binding protein that interacts with cellular membranes. Annexin IV binds to acidic phospholipids in a calcium-dependent manner, forming a complex that can modulate membrane permeability and control the movement of certain ions, such as calcium and potassium, across membranes.
Additionally, annexin IV has been implicated in several physiological and pathological conditions. For instance, studies have linked annexin IV to the inhibition of blood clot formation, suggesting its potential role as an anticoagulant. It has also been associated with the development of different cancers, including ovarian, gastric, and pancreatic cancer. Current research is focused on understanding the precise mechanisms through which annexin IV functions and its potential use as a diagnostic or therapeutic target for various diseases.
In conclusion, annexin IV is a calcium-dependent phospholipid-binding protein that plays important roles in cellular processes, such as ion transport and signal transduction. It is involved in maintaining calcium homeostasis and regulating membrane permeability. Further research is required to fully elucidate the functions and potential clinical applications of annexin IV.
Common Misspellings for ANNEXIN IV
Etymology of ANNEXIN IV
The word "Annexin IV" does not have a specific etymology on its own as it is a scientific term used to identify a protein. However, it is part of the broader category of "annexins".
The term "annexin" comes from the Latin word "annexus", which means "attached" or "connected". It was coined due to the protein's ability to attach or bind to cell membranes in a calcium-dependent manner. The "IV" in "Annexin IV" typically denotes the fourth identified member within the annexin protein family or a specific isoform or variant of Annexin IV.
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