CONTACT GUIDANCE Meaning and
Definition
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Contact guidance is a phenomenon found in cell biology and tissue engineering, where cells exhibit certain behaviors and orientations in response to physical contact with their surrounding environment. It refers to the process by which cells receive and interpret mechanical signals from their immediate surroundings, which then influences their migration, polarization, and alignment.
In contact guidance, cells possess specialized structures, such as filopodia and lamellipodia, that sense and respond to physical cues in their surrounding environment. These cues can include the presence of specific proteins in the extracellular matrix or the physical topography of the substrate on which the cells are adhered. When cells come into contact with these cues, they undergo various morphological changes and reorganization of their cytoskeleton to align themselves along the defined direction or topographical features of their substrate.
This guidance mechanism plays a crucial role in various biological processes, such as embryonic development, wound healing, and tissue regeneration. It helps to direct and guide cells towards their targeted destinations, ensuring proper tissue formation and organization. In tissue engineering, contact guidance is also harnessed to regulate cell behavior and direct tissue growth on engineered scaffolds, allowing for the creation of functional tissues that mimic natural physiological processes.
Overall, contact guidance is a fundamental process by which cells interpret and respond to physical cues in their microenvironment, leading to appropriate cellular behaviors and tissue organization.
Common Misspellings for CONTACT GUIDANCE
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Etymology of CONTACT GUIDANCE
The term "contact guidance" is a scientific term used in the field of cell biology and tissue engineering, specifically related to cells' behavior and movement in response to physical contact with their surroundings. The etymology of the word can be broken down as follows:
1. Contact: The term "contact" originated from the Latin word "contactus", which is the past participle of "contingere", meaning "to touch or come into contact with". It is composed of the Latin prefix "con-" (meaning "together" or "with") and "tangere" (meaning "to touch").
2. Guidance: The term "guidance" has its root in the Old French word "guidance", which came from the verb "guider" meaning "to guide" or "to lead". It traces back to the Germanic word "witan" meaning "to look after" or "to observe".
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