ENDOTHELIUM DERIVED VASOCONSTRICTOR FACTORS Meaning and
Definition
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Endothelium Derived Vasoconstrictor Factors (EDVFs) refer to a group of substances that are produced and released by the endothelium, which is the inner lining of blood vessels. These factors play a crucial role in regulating the diameter of blood vessels and thus influencing blood flow and blood pressure.
EDVFs have vasoconstrictive properties, meaning they cause the constriction or narrowing of the blood vessels. This constriction reduces the vessel diameter, resulting in increased resistance to blood flow. As a consequence, blood pressure rises.
There are several types of EDVFs, including endothelin-1 (ET-1), angiotensin II (Ang II), and thromboxane A2 (TXA2). Endothelin-1 is considered one of the most potent known vasoconstrictors and is mainly produced by endothelial cells in response to various stimuli. Angiotensin II is a hormone that is involved in regulating blood pressure and is generated by the renin-angiotensin system. Thromboxane A2 is an eicosanoid produced by platelets and has a strong constrictive effect on blood vessels.
The release of EDVFs is regulated by a delicate balance with their counterparts, endothelium-derived vasodilator factors, which promote relaxation and widening of blood vessels. This balance is crucial for maintaining appropriate vascular tone and blood pressure regulation.
Dysfunction or imbalance in the production and release of EDVFs can lead to pathological conditions such as hypertension and cardiovascular diseases. Understanding the role and regulation of EDVFs is important for developing therapeutic strategies to manage these conditions and maintain vascular health.
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