How Do You Spell LISSENCEPHALOUS?

1. Lissencephalous is an adjective that describes a medical condition in which the normal folding of the cerebral cortex, the outer layer of the brain, fails to develop properly. In a healthy brain, the cerebral cortex undergoes extensive folding during fetal development, resulting in a complex and characteristic pattern of ridges and grooves, called gyri and sulci respectively. In lissencephaly, however, the surface of the brain appears unusually smooth and lacking the typical convolutions.

   This condition is typically caused by a genetic mutation or abnormality during the early stages of brain development. It is a rare disorder that can lead to significant neurological problems, including developmental delays, intellectual disability, seizures, and abnormal muscle tone. The severity of these symptoms can vary widely depending on the individual, with some cases being more severe than others.

   Diagnosis of lissencephaly is often made through neuroimaging techniques, such as magnetic resonance imaging (MRI). Treatment options for lissencephaly are limited and primarily focus on managing the associated symptoms. This may include the use of anticonvulsant medications to control seizures, physical therapy to address motor impairments, and supportive interventions to assist with developmental delays.

   In summary, lissencephalous refers to a condition characterized by the absence or reduction of normal brain folding, resulting in a smooth cerebral cortex and various neurological manifestations.

Common Misspellings for LISSENCEPHALOUS

The word "lissencephalous" is derived from the combination of two Greek roots: "lissos" and "enkephalos".

The Greek root "lissos" (λισσός) means "smooth, even, or plain". It is commonly used in medical terminology to describe the absence of wrinkles or folds.

The second root "enkephalos" (ἐγκέφαλος) represents "the brain". It is derived from "en" meaning "in" and "kephale" meaning "head".

By combining these roots, the term "lissencephalous" is formed, which describes a condition where the brain lacks the usual folds and convolutions, resulting in a smooth appearance.