NEUROFILAMENT GENE Meaning and
Definition
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The neurofilament gene refers to a specific gene that is responsible for the production of neurofilaments within a cell. Neurofilaments are a type of protein filament found predominantly within the neurons of the central nervous system (CNS). These filaments play a critical role in maintaining the structural integrity of neurons and their axons, which are responsible for transmitting electrical signals between cells.
The neurofilament gene, otherwise known as NEFL, codes for the production of the light neurofilament protein (NFL). This protein is one of three types of neurofilament proteins found in neurons, with the others being medium and heavy neurofilaments. The expression of the neurofilament gene is primarily restricted to neurons, and its levels can vary depending on the specific cell type and developmental stage.
Mutations or disruptions in the neurofilament gene have been implicated in various neurological disorders, including Charcot-Marie-Tooth disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease. These conditions are characterized by degeneration and dysfunction of neurons, leading to motor and cognitive impairments.
Due to their involvement in various neurodegenerative diseases, neurofilament proteins and the neurofilament gene have become important targets for research related to diagnostic and therapeutic advancements. By studying the role of neurofilament gene expression and its relationship with neurodegenerative disorders, scientists hope to develop better diagnostic tools and identify potential therapeutic targets for these debilitating conditions.
Common Misspellings for NEUROFILAMENT GENE
- beurofilament gene
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- nwurofilament gene
- nsurofilament gene
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- neueofilament gene
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- neufofilament gene
- neutofilament gene
Etymology of NEUROFILAMENT GENE
The term "neurofilament gene" is a compound word consisting of "neurofilament" and "gene". Let's break down the etymology of these two words:
1. Neurofilament:
- "Neuro-" is derived from the Greek word "neuron", which means "nerve" or "sinew".
- "Filament" comes from the Latin word "filum", meaning "thread" or "string".
Neurofilaments are structural proteins found in nerve cells, specifically in the cytoplasmic region, responsible for maintaining the stability and structural integrity of neurons.
2. Gene:
- "Gene" originates from the German word "gen", coined by Danish scientist Wilhelm Johannsen in 1909. It refers to the hereditary factors that determine specific traits in living organisms.
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