TRANSPORTINS Meaning and
Definition
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Transportins are protein molecules involved in the intracellular transportation and localization of other proteins. They play a crucial role in the regulation of cellular processes by ensuring the correct localization of proteins within the cell.
Functioning as molecular shuttles, transportins bind to specific proteins and navigate them through the complex network of the cell. They recognize specific nuclear localization signals (NLS) present in cargo proteins, enabling their transport from the cytoplasm into the nucleus or vice versa. Transportins belong to a class of molecules called importins, which are responsible for the transport of proteins across the nuclear membrane.
Transportins typically consist of multiple domains, including an N-terminal importin beta-binding (IBB) domain and a C-terminal region that interacts with the cargo proteins. The IBB domain regulates the binding and release of cargo proteins by importins, providing a dynamic control over the transport process. Through the recognition and binding of the cargo proteins, transportins facilitate the transport of these proteins to their target compartments, aiding in their proper localization within the cell.
The activity of transportins is tightly regulated by various factors, including the presence of Ran GTPase and nuclear pore complex proteins. Ran GTPase acts as a molecular switch that regulates the association and dissociation of transportins with their cargo proteins. The integration of these regulatory mechanisms ensures the efficient and accurate transportation of proteins to their appropriate cellular locations, contributing to the maintenance of cellular homeostasis and proper cellular functions.
Common Misspellings for TRANSPORTINS
- rransportins
- fransportins
- gransportins
- yransportins
- 6ransportins
- 5ransportins
- teansportins
- tdansportins
- tfansportins
- ttansportins
- t5ansportins
- t4ansportins
- trznsportins
- trsnsportins
- trwnsportins
- trqnsportins
- trabsportins
- tramsportins
- trajsportins
- trahsportins
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