CARNITINE ACYLTRANSFERASE I Meaning and
Definition
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Carnitine acyltransferase I (CAT-I) is a crucial enzyme involved in the beta-oxidation of fatty acids in cells. It is primarily found in the mitochondria, which are the cellular organelles responsible for generating energy. Specifically, CAT-I is responsible for the transportation of fatty acids into the mitochondrial matrix, where further degradation and energy production take place.
CAT-I performs its function by catalyzing the transfer of long-chain fatty acyl groups from coenzyme A (CoA) to carnitine. This process allows the fatty acids to cross the inner mitochondrial membrane, which is impermeable to CoA. Once inside the mitochondria, the acylcarnitine is reconverted into acyl-CoA by the enzyme carnitine acyltransferase II (CAT-II), enabling the continuation of beta-oxidation.
The activity of CAT-I is tightly regulated in order to maintain the balance between cellular energy requirements and fatty acid metabolism. Several factors, such as the presence of malonyl-CoA, influence the activity of CAT-I. Malonyl-CoA acts as an inhibitor, preventing the transport of fatty acids into the mitochondria when there is ample energy supply or glucose availability.
Defects or deficiencies in the activity of CAT-I have been associated with various metabolic disorders, including fatty acid oxidation disorders. These disorders can lead to the accumulation of fatty acids in tissues, resulting in symptoms such as muscle weakness, hypoglycemia, and cardiac abnormalities.
Common Misspellings for CARNITINE ACYLTRANSFERASE I
- xarnitine acyltransferase i
- varnitine acyltransferase i
- farnitine acyltransferase i
- darnitine acyltransferase i
- czrnitine acyltransferase i
- csrnitine acyltransferase i
- cwrnitine acyltransferase i
- cqrnitine acyltransferase i
- caenitine acyltransferase i
- cadnitine acyltransferase i
- cafnitine acyltransferase i
- catnitine acyltransferase i
- ca5nitine acyltransferase i
- ca4nitine acyltransferase i
- carbitine acyltransferase i
- carmitine acyltransferase i
- carjitine acyltransferase i
- carhitine acyltransferase i
- carnutine acyltransferase i
- carnjtine acyltransferase i
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