CARNITINE O PALMITOYLTRANSFERASE Meaning and
Definition
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Carnitine O-palmitoyltransferase (CPT) is an enzyme that plays a crucial role in fatty acid metabolism. It aids in the transport of long-chain fatty acids from the cytoplasm into the mitochondria for subsequent beta-oxidation, which is the primary process by which fatty acids are broken down to produce energy.
CPT consists of several isoforms, with CPT I and CPT II being the most widely recognized. CPT I is mainly located on the outer mitochondrial membrane, where it catalyzes the esterification of long-chain fatty acids with carnitine, forming acylcarnitines. This process allows the acylcarnitines to cross the mitochondrial membrane via the carnitine-acylcarnitine translocase, gaining access to the mitochondrial matrix.
On the other hand, CPT II is predominantly found on the inner mitochondrial membrane. Once inside the mitochondrial matrix, acylcarnitine is converted back to acyl-CoA by CPT II, enabling the long-chain fatty acids to undergo beta-oxidation and generate ATP, the primary energy currency of cells.
The activity of CPT is tightly regulated and influenced by various factors, including hormonal and nutritional signals. CPT deficiencies or dysfunction can lead to disorders characterized by impaired fatty acid oxidation, such as carnitine palmitoyltransferase I deficiency or CPT II deficiency, resulting in the accumulation of acylcarnitines and subsequent metabolic disturbances.
Common Misspellings for CARNITINE O PALMITOYLTRANSFERASE
- xarnitine o palmitoyltransferase
- varnitine o palmitoyltransferase
- farnitine o palmitoyltransferase
- darnitine o palmitoyltransferase
- czrnitine o palmitoyltransferase
- csrnitine o palmitoyltransferase
- cwrnitine o palmitoyltransferase
- cqrnitine o palmitoyltransferase
- caenitine o palmitoyltransferase
- cadnitine o palmitoyltransferase
- cafnitine o palmitoyltransferase
- catnitine o palmitoyltransferase
- ca5nitine o palmitoyltransferase
- ca4nitine o palmitoyltransferase
- carbitine o palmitoyltransferase
- carmitine o palmitoyltransferase
- carjitine o palmitoyltransferase
- carhitine o palmitoyltransferase
- carnutine o palmitoyltransferase
- carnjtine o palmitoyltransferase
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