POLYMERIC IMMUNOGLOBULIN RECEPTOR Meaning and
Definition
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The polymeric immunoglobulin receptor (pIgR) is a protein found on the surface of epithelial cells, particularly those lining the respiratory, gastrointestinal, and genitourinary tracts. It plays a vital role in the transport of immunoglobulins, or antibodies, across these mucosal surfaces.
The pIgR is part of the body's immune defense system, providing a mechanism for the mucosal tissues to receive protection from various pathogens. It is responsible for the selective uptake of polymeric immunoglobulin A (IgA), the most abundant class of antibodies in mucosal secretions, from the bloodstream to the mucosal surfaces.
Once synthesized by plasma cells in the lamina propria beneath the epithelial layer, polymeric IgA binds to the pIgR on the basolateral side of the epithelial cell. This binding triggers the endocytosis of the pIgR-IgA complex into the cell. The pIgR then carries the IgA across the epithelial cell cytoplasm and releases it on the apical side (mucosal surface) by a process called transcytosis. In this way, the pIgR acts as a transport shuttle, delivering IgA antibodies to the mucosal surfaces to provide localized protection against pathogens.
The pIgR also plays a role in immune surveillance, as its presence on the mucosal surfaces can facilitate the capture of antigens and present them to immune cells, further contributing to the immune response. Overall, the polymeric immunoglobulin receptor is an essential component of the mucosal immune system, ensuring the delivery of protective antibodies to the mucosal surfaces and assisting in immune surveillance.
Common Misspellings for POLYMERIC IMMUNOGLOBULIN RECEPTOR
- oolymeric immunoglobulin receptor
- lolymeric immunoglobulin receptor
- -olymeric immunoglobulin receptor
- 0olymeric immunoglobulin receptor
- pilymeric immunoglobulin receptor
- pklymeric immunoglobulin receptor
- pllymeric immunoglobulin receptor
- pplymeric immunoglobulin receptor
- p0lymeric immunoglobulin receptor
- p9lymeric immunoglobulin receptor
- pokymeric immunoglobulin receptor
- popymeric immunoglobulin receptor
- pooymeric immunoglobulin receptor
- poltmeric immunoglobulin receptor
- polgmeric immunoglobulin receptor
- polhmeric immunoglobulin receptor
- polumeric immunoglobulin receptor
- pol7meric immunoglobulin receptor
- pol6meric immunoglobulin receptor
- polyneric immunoglobulin receptor
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